Assessment of established HDL-C loci for association with HDL-C levels and type 2 diabetes in Pima Indians

HDL-C and HDL-C/ApoA-I predict long-term progression of glycemia in established type 2 diabetes.

OBJECTIVE Low HDL cholesterol (HDL-C) and small HDL particle size may directly promote hyperglycemia. We evaluated associations of HDL-C, apolipoprotein A-I (apoA-I), and HDL-C/apoA-I with insulin secretion, insulin resistance, HbA1c, and long-term glycemic deterioration, reflected by initiation of pharmacologic glucose control. RESEARCH DESIGN AND METHODS The 5-year Fenofibrate Intervention ...

Association of HDL & HDL subfraction levels with Microalbuminuria, in Type 1 Diabetes

Phosphatidylinositol increases HDL-C levels in humans.

Studies have shown that phosphatidylinositol (PI) can stimulate reverse cholesterol transport by enhancing the flux of cholesterol into HDL and by promoting the transport of high density lipoprotein-cholesterol (HDL-C) to the liver and bile. The goal of this study was to determine the safety and therapeutic value of PI after oral administration to normolipidemic human subjects. We performed a r...

Association between LDL-C, Non HDL-C, and Apolipoprotein B Levels with Coronary Plaque Regression

BACKGROUND Previous reports have inferred a linear relationship between LDL-C and changes in coronary plaque volume (CPV) measured by intravascular ultrasound. However, these publications included a small number of studies and did not explore other lipid markers. OBJECTIVE To assess the association between changes in lipid markers and regression of CPV using published data. METHODS We colle...

Severe HDL-c reduction during rosiglitazone therapy in an obese woman with type 2 diabetes.

Treatment with rosiglitazone has been associated with severe paradoxical HDL-c reductions. To our knowledge, there are very few reports of this reaction occurring when patients are treated without the combination of a fibrate. A case of severe HDL-c lowering in a patient treated with rosiglitazone without a fibrate is presented. The patient has been treated at a private practice clinic in south...